SUPPRESSION OF DNA-SYNTHESIS BY CON A-ACTIVATED HUMAN-LYMPHOCYTES - ROLE OF MONOCYTES IN CON A-INDUCED SUPPRESSION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (3) , 583-590
Abstract
Human peripheral blood mononuclear leukocytes activated by Con [concanavalin] A, suppress the antigen- or mitogen-induced proliferation of autologous responder cells. Generation of suppressor cells is prevented by mitomycin treatment before Con A activation. Once cells are activated, their suppressive activity is not affected by mitomycin treatment. Monocytes are required for generation of suppressor cells and are involved in suppression as effector cells. Monocyte-mediated suppression is blocked by indomethacin, suggesting that this suppression is mediated by prostaglandins. Monocytes apparently are involved in Con A-induced suppression of DNA synthesis.