Stimulation of Blastocyst Implantation in Long Term Hypophysectomized and Ovariectomized Pregnant Rats by Means of Androgens

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Abstract
About 140 rats were subjected to one or more of the following operative procedures to study the hormonal factors involved in nidation: hypophysectomy, ovariectomy, adrenalectomy and partial hepatectomy. A single dose of four different androgens induced nidation in hypophysectomized pregnant rats treated with progesterone. Testosterone propionate (TP) and related androgens were more effective than 5α-androstane. The minimal effective dose of TP was 0.008 mg when applied to the ovarian capsule; 1.0 mg intramuscularly was required in animals ovariectomized prior to progesterone-androgen treatment. There was no evidence of a direct effect of androgens on implantation since a high dose of TP (50 µg) applied directly to the uterine mesometrium failed to stimulate nidation in hypophysectomized animals which were ovariectomized prior to TP and progesterone treatment.

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