Immunogenicity and Immunological Priming of the Serogroup A Portion of a Bivalent Meningococcal A/C Conjugate Vaccine in 2‐Year‐Old Children
Open Access
- 1 April 2003
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 187 (7) , 1142-1146
- https://doi.org/10.1086/368358
Abstract
Two-year-old children were vaccinated with 1 dose of meningococcal A/C conjugate (MACC) or meningococcal A/C polysaccharide (MACP) vaccine. Meningococcal serogroup A (MenA)–specific IgG geometric mean avidity indices (GMAIs) increased 1 month after vaccination with MACC (GMAI, 210; 95% confidence interval [CI], 140–300) and MACP (GMAI, 190; 95% CI, 120–310). One year after vaccination, the GMAI of the MACP-vaccinated cohort decreased to 130 (95%, CI 100–170), but a constant GMAI was maintained in the MACC-vaccinated cohort (210; 95% CI, 140–300), despite declining MenA-specific IgG antibody levelsKeywords
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