An immune factor in baboon anti-candida serum

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Abstract
The susceptibility of the baboon (Papio sp. - Kenya, East Africa) to Candida albicans infection studied and compared with that of rabbits. Each animal was injected intravenously with 5 × 106 particles of C. albicans in 1 ml. saline. The baboon (which died 5 days post-inoculation) was found to be more susceptible than rabbit. Baboon anti-Candida serum was given intramuscularly for 4 weeks to immunize passively 2 baboons which were then challenged with a dose containing the same number of viable particles; they survived this and similar booster injected 3 weeks later. Serum obtained from these baboons when killed 6-week post-inoculation, was used to immunize 2 more baboons, which survived a challenge dose and 2 boosters, 3 weeks apart. When exactly the same procedure was applied to rabbits, using rabbit anti-Candida serum, the serum failed to protect or lengthen survival time over that of control animals. A hypothesis was adopted: an “immune factor” is found in the serum of infected baboons which can produce “tissue-bound” or cell-mediated immunity in passively immunized baboons. These antibodies or sensitized cells provide protection to challenged recipients.

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