STIMULATION OF SYNAPTOSOMAL PROLINE UPTAKE BY SERUM ALBUMIN
- 1 September 1979
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 33 (3) , 739-743
- https://doi.org/10.1111/j.1471-4159.1979.tb05219.x
Abstract
Abstract— The accumulation of proline by synaptosomal fractions from adult brain cortices is strongly stimulated by serum albumin. Albumin at a concentration of 1 mg/ml increased the recovery of proline from the fraction by approx 2‐fold. This effect was not due to any contaminant but rather due to the albumin molecule itself. Several other proteins tested failed to stimulate synaptosomal accumulation of proline, indicating that the stimulation due to albumin is not a general protein effect. The possibility that albumin stimulates synaptosomal proline accumulation by virtue of its fatty acid binding property is discussed.This publication has 16 references indexed in Scilit:
- Serum albumin stimulation of synaptosomal proline uptake: Partial identification of the active siteBiochemical and Biophysical Research Communications, 1978
- STRUCTURAL REQUIREMENTS FOR AMINO ACID INHIBITION OF Na+‐DEPENDENT PROLINE UPTAKE BY RAT BRAIN SYNAPTOSOMESJournal of Neurochemistry, 1977
- Amino acid inhibition of sodium-dependent synaptosomal proline uptakeNeuroscience Letters, 1977
- Inactivation by detergents of the proline transport system in membrane vesicles from Escherichia coli and its reactivation by bovine serum albuminBiochimica et Biophysica Acta (BBA) - Biomembranes, 1976
- Fragments of bovine serum albumin produced by limited proteolysis. Conformation and ligand bindingBiochemistry, 1975
- Histamine as a transmitter in brainLife Sciences, 1975
- Microiontophoretic studies of the effects of L-proline on neurons in the mammalian central nervous systemBrain Research, 1975
- Iontophoretic and autoradiographic studies on the role of proline in nervous transmissionPflügers Archiv - European Journal of Physiology, 1974
- Absence of a specific copper(II) binding site in dog albumin is due to amino acid mutation in position 3Biochemical and Biophysical Research Communications, 1972
- CHARACTERISTICS OF AMINO ACID ACCUMULATION BY SYNAPTOSOMAL PARTICLES ISOLATED FROM RAT BRAINJournal of Neurochemistry, 1972