Experimental Studies on Pathogenesis of Hemoglobinuric Nephrosis

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Abstract
Prolonged hemorrhagic shock was produced in 13 dogs. This was followed by infusions of hemolyzed blood with or without red blood cell stroma. The animals were then brought out of shock with transfusions of their own blood. 4 dogs died within 17 hrs. of anesthetic complications or "irreversible" shock. The 9 surviving dogs revealed no evidence of hemoglobinuric nephrosis, and were completely well within 20 hrs. In this study, the combination of prolonged hemorrhagic shock and hemoglobinuria failed to produce hemoglobinuric nephrosis.

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