Pyruvate and Glucose as Precursors of Acetoacetate

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Abstract
In mammary and kidney homogenates incubated with various C14-labeled substrates, acetate and pyruvate were strongly ketogenic, whereas glucose and lactate gave rise to only small amounts of acetoacetate. The analogous behavior of glucose and lactate, in contrast with that of pyruvate, indicates that the low ketogenicity of glucose and its ability to stimulate lipogenesis is associated with the regeneration of reduced pyridine nucleotides during its breakdown.