CAUDAL ANESTHESIA WITH LIDOCAINE OR BUPIVACAINE - PLASMA LOCAL-ANESTHETIC CONCENTRATION AND EXTENT OF SENSORY SPREAD IN OLD AND YOUNG-PATIENTS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 63  (11) , 1017-1020
Abstract
Continuous caudal peridural anesthesia with 2% lidocaine (6 mg/kg) or 0.75% bupivacaine (2.2 mg/kg), both with epinephrine 1:200,000, was studied in 2 groups of male patients, < 40 or > 55 yr old, respectively. Patients receiving lidocaine in the younger group (n = 6) were 32 .+-. 5.2 (mean .+-. SD) yr old and weighed 75 .+-. 12 kg, while those in the older group (n = 16) were 66 .+-. 5.3 yr old and weighed 72 .+-. 8.2 kg. Patients receiving bupivacaine in the respective groups were 27 .+-. 7.0 yr old (n = 5) and 76 .+-. 10 kg compared to 69 .+-. 10 yr (n = 14) and 75 .+-. 10 kg. Anesthesia was satisfactory in all patients. Extent of sensory anesthesia, peak plasma lidocaine or bupivacaine concentrations, and area under the plasma concentration-time curves were independent of age. No local anesthetic toxicity was observed and peak drug concentrations were below those commonly associated with toxicity.

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