Genetic control of glucokinase activity in mice
- 1 April 1977
- journal article
- research article
- Published by Springer Nature in Biochemical Genetics
- Vol. 15 (3-4) , 297-305
- https://doi.org/10.1007/bf00484461
Abstract
Inbred strains of mice were surveyed for liver glucokinase activity. Mice of all strains studied could be distributed into three groups with high, intermediate, and low levels of enzyme activity. Genetic analysis using crosses and backcrosses with prototype high (C3H/HeJ) and low (RF/J) strains revealed that glucokinase activity was controlled by a single gene. The name “glucokinase” and gene symbol Gk are suggested for this gene. The Gk a allele designates the strain with high glucokinase activity, while Gk b represents the allele in the strain with the low enzyme activity. The interaction of fasting and diabetes on the activity of glucokinase in these two strains is described.Keywords
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