Prognostic Value of Ki-67 for Recurrence and Progression of Superficial Bladder Cancer

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Abstract
We retrospectively reviewed 104 cases of superficial bladder cancer to ascertain whether the Ki-67 labeling index predicts recurrence and progression. Archival specimens from superficial bladder cancer cases were immunostained with Ki-67. The recurrence rate was significantly higher in cases with a Ki-67 labeling index of 5.35 or greater than in those with a value less than 5.35 (p <0.001). The recurrence rate at 2 years was 70% in cases with a Ki-67 labeling index of 5.35 or greater and 22% in those with an index less than 5.35 (p <0.001). Using multivariate analysis the index predicted recurrence of bladder cancer (p <0.005). Median Ki-67 labeling index in cases with progression was significantly higher than in those without progression (p <0.01). The Ki-67 labeling index is an independent predictive factor for recurrence of superficial bladder cancer.