Antifertility and Hormonal Properties of Certain Carotane Sesquiterpenes ofFerula jaeschkeana*
- 1 December 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 54 (06) , 492-494
- https://doi.org/10.1055/s-2006-962526
Abstract
Of the 7 carotane sesquiterpenes of Ferula jaeschkeana Vatke evaluated, three jaeschkeanadiol esters (compounds 3, 5, and 6) showed contraceptive efficacy when administered orally on days 1-7 post coitum in rats. In ovariectomized immature female rats, however, the active compounds exhibited estrogenic activity and were devoid of antiestrogenic activity. Using a competitive protein binding assay, the compounds 3, 5, and 6 showed relative binding affinity of 0.01%, 5.75%, and 0.75% of 17β-estradiol, respectively, for rat uterine cytosol estrogen receptors.This publication has 4 references indexed in Scilit:
- Carotane derivatives from Ferula jaeschkeanaPublished by Elsevier ,2001
- New Sesquiterpenes fromFerula jaeschkeanaPlanta Medica, 1987
- Studies in antifertility agents — Part XLI: Secosteroids — X: Syntheses of various stereoisomers of (±) 2,6β-diethyl-7α-ethynyl-3-(?-hydroxyphenyl)-?-bicyclo[4.3.0]nonan-7β-olSteroids, 1983
- Effect of Estrogens and Other Compounds as Oral Antifertility Agents on the Development of Rabbit Ova and Hamster EmbryosFertility and Sterility, 1965