The chronic toxicity of p-nitrophenyl diethyl thiophosphate (E. 605): A long-term feeding experiment with rats

Publisher Website
Google Scholar
Abstract
Albino rats were fed diets containing 10 to 100 ppm. of the insecticide p-nitrophenyl diethyl thiophosphate (E. 605, Parathion). At 100 and 75 ppm., signs of acute toxic ity appeared in a few hrs. and most of the rats died. On return of survivors to normal diet, symptoms disappeared within 24 hrs. At 50 ppm., a few deaths occurred, and symptoms occurred intermittently for a year. In animals fed 20 and 10 ppm. there was no evidence of poisoning; however, on breeding, the 2d generation of rats fed 20 ppm. produced many dead offspring. Histological examination of animals dead from poisoning showed hypoplasia of the spleen and thymus, and vacuola-tion of the pancreas and submaxillary glands.