Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey

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Abstract
Upper respiratory tract infection (URTI), or the “common cold,” is the most widespread infectious disease and the most common reason for US emergency department visits and unscheduled outpatient visits.1 More than 200 viruses contribute to the clinical syndrome of cough, nasal congestion, nasal discharge, sore throat, and sneezing.2,3 Most adults in the United States experience 2 to 4 URTIs per year, and most children experience 6 to 10 per year, which carries enormous population morbidity due to the high incidence of disease and disruption caused by symptoms.4,5