Toxicity of aromatic disulphides. II. Intra‐erythrocytic hydrogen peroxide formation and oxidative damage by aromatic disulphides

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Abstract
Diphenyl disulphide has been shown to generate hydrogen peroxide in erythrocytes in vitro. It also induces oxidative damage (reversible and irreversible haemoglobin oxidation, depletion of non-protein and protein-bound thiols) in these cells. Such changes were also recorded in erythrocytes exposed to 4,4′ -diaminodiphenyl disulphide, 2,2′-diaminodiphenyl disulphide, 4,4′-dimethyldiphenyl disulphide, 4,4′-dinitrodiphenyl disulphide, diphenyl disulphide-2,2′-dicarboxylic acid and dibenzyl disulphide. The relative potency of these coumpounds in causing erythrocyte damage is correlated with their ability to generate ‘active oxygen’ species in vitro.