Correlation between disease activity and T‐cell CD3 chain expression in a B‐cell lymphoma
- 1 December 1994
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 88 (4) , 886-888
- https://doi.org/10.1111/j.1365-2141.1994.tb05133.x
Abstract
Summary. The T-cell receptor (TCR)/CD3 complex is the surface molecule responsible for the highly specific response to foreign antigens, including tumour-associated antigens. T-cell responses are frequently defective in cancer patients, and correlations have been observed with disease status. Recently, low amounts of CD3γ and CD3 chains in the CD3/TCR complex have been reported in long-term tumour-bearing mice as a possible mechanism for the impaired T-cell responses. In this study we report a B-cell lymphoma in which T-cell CD3 expression correlated with disease activity.Keywords
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