Mechanism of Action of Thrombin on Fibrinogen, I. Synthesis of Fibrinogen-like Peptides, and Their Proteolysis by Thrombin and Trypsin
- 1 February 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (2) , 253-256
- https://doi.org/10.1073/pnas.68.2.253
Abstract
In a study of the action of thrombin on fibrinogen and a comparison of this enzyme with trypsin, several fibrinogen-like oligopeptides were synthesized. The hydrolysis of the arginyl-glycine bond in these peptides, by both of these enzymes, is examined and compared.Keywords
This publication has 21 references indexed in Scilit:
- Purification and properties of bovine prothrombinBiochemistry, 1969
- Solid-Phase Peptide Synthesis. III. An Improved Synthesis of Bradykinin*Biochemistry, 1964
- Amino-Acid Sequence Investigations of Fibrinopeptides from Various Mammals: Evolutionary ImplicationsNature, 1964
- The Effect of Certain Proteolytic Enzymes on the Thrombin-Fibrinogen Interaction*Biochemistry, 1962
- THROMBIN-INDUCED FORMATION OF CO-FIBRIN .3. ACID DEGRADATION STUDIES AND SUMMARY OF SEQUENTIAL EVIDENCE ON PEPTIDE-A1959
- THROMBIN-INDUCED FORMATION OF CO-FIBRIN .1. ISOLATION, PURIFICATION, AND CHARACTERIZATION OF CO-FIBRIN1959
- Action du chlorure de sodium sur l'autolyse de la trypsineBiochimica et Biophysica Acta, 1959
- OBSERVATIONS ON THE ANALYSIS FOR THROMBIN AND THE INACTIVATION OF FIBRIN MONOMERJournal of Biological Chemistry, 1957
- The effect of arginylpeptides on the clotting of fibrinogen with thrombinBiochimica et Biophysica Acta, 1957
- THE ACTION OF THROMBIN ON SYNTHETIC SUBSTRATESJournal of Biological Chemistry, 1954