GOLD-195M, AN ULTRA-SHORT-LIVED GENERATOR-PRODUCED RADIONUCLIDE - CLINICAL-APPLICATION IN SEQUENTIAL 1ST PASS VENTRICULOGRAPHY

  • 1 January 1983
    • journal article
    • research article
    • Vol. 24  (2) , 139-144
Abstract
195mAu has a half-life [T1/2] of 30.5 s and can be produced at the bedside from the parent 195mHg (T1/2= 41.6 h). The generator produced sterile pyrogen-free 195mAu with Hg breakthrough of 0.75 .+-. 0.09 .mu.Ci/mCi 195mAu. Approximately 20-25 mCi of 195mAu was produced per elution from a generator containing 155 mCi of 195mHg. First-pass resting 99mTc angiograms were compared with 195mAu angiograms in 28 patients. The correlation coefficient between the 2 studies was 0.92 over an ejection-fraction range from 0.22-0.83. The reproducibility of 195mAu 1st-pass angiograms were tested by performing 2 studies 3 min apart. In 25 patients with ejection fractions ranging from 0.20-0.78, the correlation coefficient between such pairs was 0.93. The nuclide is reliably and reproducibly produced, and its short half-life allows the performance of background-free sequential 1st-transit studies with unusually low radiation exposure to the patient.