Contamination of animal feedingstuffs with nicarbazin: investigations in a feed mill

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Abstract
Some mechanisms of nicarbazin contamination were investigated in a feed mill. Three sequential 3-tonne batches of nicarbazin-free feed were produced directly after a batch of nicarbazin-containing feed (125 mg kg-1). Sampling of the nicarbazin-free feed took place at two points before pelleting and at one point post-pelleting. The study was repeated on two further occasions, i.e. three separate nicarbazin-containing feeds and 27 tonnes of <>feeds were manufactured and sampled in total. Pre-pelleting, the highest nicarbazin concentrations (3.4± 0.26 mg kg-1) were observed in the first tonne milled after the nicarbazin containing ration. Thereafter, concentrations steadily declined in successive batches. Post-pelleting samples contained much higher concentrations of the drug. After 8 tonnes had passed through, the concentrations (7.2± 1.29 mg kg-1) were between 10 and 20 times greater than the corresponding concentrations detected post-mixing. These concentrations are sufficient to cause violative residues in eggs and broiler liver. The practice of returning post-press sieved material to the pre-press bins was identified as the cause of the problem. Re-routing of sieved material along with better segregation of nicarbazin-containing and nicarbazin-free feedingstuffs markedly reduced the incidence of feed contamination with this compound.

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