Gamma Irradiation Effects on Solid Ribonuclease

Abstract
There are definite indications for structural unfolding of the ribonuclease molecule on gamma-irradiation in the solid state (increase in viscosity and increase in negative optical rotation), conconmitant with the loss in enzymatic activity. Disulfide interchange does not occur to any appreciable extent. The data establish that the number average molecular weight of the enzyme is not changed by the irradiation.

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