In Vitro Evaluation of Three Iodine-Containing Compounds as Antiplaque Agents

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Abstract
The antibacterial activity of three iodine-containing compounds was determined for strains of four dental plaque-forming microorganisms, using an in vitro preclinical plaque model system. Solutions of inorganic iodine, povidone-iodine, and Wescodyne were tested for antiplaque activity against preformed plaques of a number of strains of Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus , and Actinomyces naeslundii . Solutions of inorganic iodine were more effective as antiplaque agents, with respect to minimal bactericidal concentration and time and frequency of treatments, than solutions of Wescodyne and povidone-iodine. Inorganic iodine appeared to be particularly effective against the most cariogenic ( S. mutans ) and periodontopathic ( A. viscosus ) organisms while allowing survival of the least orally pathogenic plaque-forming microorganism ( S. sanguis ). It is suggested that topical application of solutions of inorganic iodine may be useful in controlling dental caries and actinomyces-associated periodontal disease.