EVALUATION of SHORT-TERM and LONG-TERM TREATMENT of the NARCOLEPSY SYNDROME WITH CLOMIPRAMINE HYDROCHLORIDE

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Abstract
Clinical examinations, questionnaires, and 24‐ or 36‐hour polygraphic recordings were performed on 21 adult patients with the narcolepsy syndrome to investigate the short‐ and long‐term effects of clomipramine HCL. Cataplexy was improved by the medication, but tolerance was observed after 4 1/2 months of treatment. Clomipramine HCL induced significant changes in the sleep EEG, chin EMG, and EOG. In two patients, clomipramine HCL caused a nocturnal myoclonia that produced insomnia. Sexual side effects were seen with clomipramine HCL, particularly in males. A combination of clomipramine HCL and L‐Dopa apparently prevented this difficulty in one patient. A rebound of cataplexy was seen during the 15 days following withdrawal of the drug. Methysergide maleate was found to be ineffective on cataplexy in four patients.

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