Deficient Concanavalin-A-induced suppressor-cell activity in patients with bronchial asthma, allergic rhinitis and atopic dermatitis

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Abstract
Concanavalin A (Con-A)-induced suppressor activity against the proliferative response of autologous lymphocytes to phytohemagglutinin was examined in the peripheral blood lymphocytes from 14 patients with bronchial asthma (BA), 10 patients with allergic rhinitis (AR) and 11 patients with atopic dermatitis (AD) and compared with 11 simultaneously studied healthy normals. Eight BA patients (57%), 8 AR patients (80%) and 5 AD patients (45%) demonstrated deficient Con-A-induced suppressor function. Abnormal suppressor cell functions could play an important role in the pathogenesis of atopic states.