2ND PRIMARY CANCERS FOLLOWING TREATMENT OF HODGKINS-DISEASE

  • 1 January 1984
    • journal article
    • research article
    • Vol. 72  (2) , 233-241
Abstract
A cohort study designed to evaluate the carcinogenicity of treatment for Hodgkin''s disease (HD) was conducted. Comprised describes 2591 patients with HD diagnosed in 1940-1975 and followed up through 1978. Second primary cancers, (14; excluding basal cell and squamous cell cancers of the skin and in situ carcinomas of the cervix uteri) were observed .gtoreq. 1 yr after diagnosis of HD, including 21 leukemias. Twenty leukemias occurred after chemotherapy. The relative risk (RR) of leukemia after intensive chemotherapy with or without radiotherapy was 136 relative to general population incidence rates. In the subgroup with both intensive chemotherapy and intensive radiotherapy, the RR of leukemia was 125. Both RR estimates differed significantly from unity. The RR of cancers other than leukemia .gtoreq. 10 yr after intensive radiotherapy relative to no intensive therapy was 19.5 (95% confidence limits: 4.8-80).