Immunoglobulin from systemic lupus erythematosus serum induces interferon release by normal mononuclear cells
Open Access
- 1 March 1986
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 29 (3) , 326-336
- https://doi.org/10.1002/art.1780290304
Abstract
Ig fractions from patients with systemic lupus erythematosus (SLE) were tested with cultured normal peripheral blood mononuclear cells for induction of interferon release. Lymphocyte eluates, euglobulins containing IgG and IgM, and IgG or IgM from DEAE or sucrose gradients all induced interferon production. Lymphocytotoxic antibody in SLE sera showed a high correlation with capacity of isolated Ig fractions to induce interferon. Most interferon produced was of the gamma type. Monoclonal SLE IgM antilymphocyte antibody induced interferon synthesis.Keywords
This publication has 41 references indexed in Scilit:
- Inhibition of soluble antigen-induced T cell proliferation by warm-reactive antibodies to activated T cells in systemic lupus erythematosus.Journal of Clinical Investigation, 1984
- Relationship between systemic lupus erythematosus T cell subsets, anti-T cell antibodies, and T cell functions.Journal of Clinical Investigation, 1984
- Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes.Journal of Clinical Investigation, 1983
- Interferon-induced 2'-5' adenylate synthetase in vivo and interferon production in vitro by lymphocytes from systemic lupus erythematosus patients with and without circulating interferon.The Journal of Experimental Medicine, 1983
- Systemic Lupus Erythematosus: Presence in Human Serum of an Unusual Acid-Labile Leukocyte InterferonScience, 1982
- Tγ cell subset specificity of lymphocyte reactive factors in juvenile rheumatoid arthritis and systemic lupus erythematosus seraArthritis & Rheumatism, 1981
- Characteristics of anti-T-cell antibodies in systemic lupus erythematosus: Evidence for selective reactivity with normal suppressor cells defined by monoclonal antibodiesClinical Immunology and Immunopathology, 1980
- Studies of Anti‐Lymphocyte Antibody in Patients with Active SLEScandinavian Journal of Immunology, 1980
- Immune Interferon in the Circulation of Patients with Autoimmune DiseaseNew England Journal of Medicine, 1979
- Lymphocyte Cytotoxic Antibodies in Systemic Lupus ErythematosusNature, 1970