Sephadex-induced granulomatous alveolitis in rat: Effects of antigen manipulation
- 19 January 1994
- journal article
- research article
- Published by Wiley in American Journal of Industrial Medicine
- Vol. 25 (1) , 73-78
- https://doi.org/10.1002/ajim.4700250119
Abstract
A granulomatous alveolitis, with multinuclear cell formation combined with an eosino‐philic peribronchiolitis, was achieved in rats by intratracheal administration of sephadex beads (G‐200, Pharmacia, Sweden). The pattern of inflammation and the degree of postgranulomatous fibrosis were substantially dampened when the particles were dispersed by ultrasonification. The animals were analyzed with bronchoalveolar lavage and tissue morphology.Keywords
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