Carvedilol increases the systemic bioavailability of oral digoxin.

Publisher Website
Google Scholar
Abstract
The effects of a single oral dose of 25 mg carvedilol on the plasma and urinary kinetics of digoxin after an oral and intravenous 0.5 mg dose, were investigated in two separate double‐blind, placebo‐controlled, period‐balanced cross‐over studies in healthy male subjects. Carvedilol increased the mean maximum plasma concentration and the area under the plasma concentration time‐curve of digoxin when administered orally. The effects were virtually confined to the first 4 h after dosing, and the apparent terminal disposition rate constant was not changed. Carvedilol did not alter the plasma and urinary kinetics of intravenously administered digoxin.

This publication has 10 references indexed in Scilit: