A double isotope technique for the evaluation of drug action on gastric evacuation and small bowel propulsion studied in the rat
Open Access
- 1 June 1973
- Vol. 14 (6) , 475-477
- https://doi.org/10.1136/gut.14.6.475
Abstract
A method to measure simultaneously gastric evacuation and small bowel propulsion in the rat is presented. The value of the method in testing drug action is described. The effect of an antidiarrhoeal agent, diphenoxylate, was analysed and it was shown that it retarded small bowel propulsion without influencing gastric evacuation.Keywords
This publication has 6 references indexed in Scilit:
- Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 4. Distribution in the rat of diphenoxylate and difenoxine.1972
- Small bowel propulsive motility in the rat. Studies with open and closed pylorus.1972
- Gastric emptying and propulsive intestinal motility following partial gastric resection, gastro-enteroanastomosis, and abdominal "trunk" vagotomy in the rat.1967
- Endoradiosonde study of propulsion and pressure activity induced by test meals, Prostigmine, and diphenoxylate in the small intestineGut, 1964
- The Motility of the Small IntestinePublished by Oxford University Press (OUP) ,1961
- Synthesis Anti-diarrhoeal Agents--I. Some Pharmacological Properties of R 1132 and Related CompoundsJournal of Medicinal Chemistry, 1959