Effects of pinaverium bromide and verapamil on the motility of the rat isolated colon
Open Access
- 1 September 1985
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 86 (1) , 89-94
- https://doi.org/10.1111/j.1476-5381.1985.tb09438.x
Abstract
Pinaverium bromide was 30 times less potent than verapamil in inhibiting intraluminal pressure responses of in vitro rat colonic segments to barium chloride, acetylcholine, FK 33–824 or field stimulation. The inhibitory effects of both verapamil and pinaverium bromide on the pressure responses to field stimulation were antagonized similarly by exogenous calcium administration. These results support the concept that pinaverium bromide acts on calcium channels in the smooth muscle cell membrane.This publication has 9 references indexed in Scilit:
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