Hepatotoxicity caused by the combined action of isoniazid and rifampicin.
Open Access
- 1 February 1995
- Vol. 50 (2) , 213-214
- https://doi.org/10.1136/thx.50.2.213
Abstract
A 35 year old black Somalian woman with miliary tuberculosis developed hepatotoxicity after a few days of treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol. After withdrawal of all drugs the liver profile returned to normal and remained so after challenge with isoniazid. Hepatotoxicity recurred when rifampicin was added, but it was well tolerated when reintroduced without isoniazid.Keywords
This publication has 5 references indexed in Scilit:
- Toxic Hepatitis with Isoniazid and RifampinChest, 1991
- Drug-induced Liver DiseaseMedical Clinics of North America, 1989
- RIFAMPIN-INDUCED RELEASE OF HYDRAZINE FROM ISONIAZID - A POSSIBLE CAUSE OF HEPATITIS DURING TREATMENT OF TUBERCULOSIS WITH REGIMENS CONTAINING ISONIAZID AND RIFAMPINPublished by Elsevier ,1986
- ISONIAZID-RELATED HEPATITIS - UNITED-STATES PUBLIC-HEALTH SERVICE COOPERATIVE SURVEILLANCE STUDYPublished by Elsevier ,1978
- Toxicity from rifampicin plus isoniazid and rifampicin plus ethambutol therapyTubercle, 1971