Inhibition of herpes simplex virus replication by genistein, an inhibitor of protein-tyrosine kinase
- 1 September 1993
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 132 (3-4) , 451-461
- https://doi.org/10.1007/bf01309554
Abstract
Genistein, an inhibitor of protein-tyrosine kinase, inhibited the replication of herpes simplex virus type 1 (HSV-1) at genistein concentrations of more than 25 µM, whereas the related compounds, which do not inhibit protein-tyrosine kinases, did not affect the replication of HSV-1. In the presence of genistein, the phosphorylation of tyrosine residues in specific viral polypeptides was markedly reduced. These results indicate that the phosphorylation of tyrosine residues in viral polypeptides may be essential for the replication of HSV-1.Keywords
This publication has 40 references indexed in Scilit:
- Participation of Tyrosine Phosphorylation in the Cytopathic Effect of Human Immunodeficiency Virus-1Science, 1992
- Heparan Sulfate as a Mediator of Herpes Simplex Virus Binding to Basement MembraneJournal of Investigative Dermatology, 1992
- The herpes simplex virus type 1 tegument protein VP22 is encoded by gene UL49Journal of General Virology, 1992
- The UL13 virion protein of herpes simplex virus type 1 is phosphorylated by a novel virus-induced protein kinaseJournal of General Virology, 1992
- Role of DNA topoisomerase I in the replication of herpes simplex virus type 2Archiv für die gesamte Virusforschung, 1990
- Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha-ras-transformed NIH 3T3 cellsBiochemical and Biophysical Research Communications, 1988
- Macromolecular synthesis at the early stage of herpes simplex virus type 2 (HSV-2) latency in a human neuroblastoma cell line IMR-32: repression of late viral polypeptide synthesis and accumulation of cellular heat-shock proteinsArchiv für die gesamte Virusforschung, 1987
- Studies on the Herpes Simplex Virus Alkaline Nuclease: Detection of Type-common and Type-specific Epitopes on the EnzymeJournal of General Virology, 1985
- Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcriptionJournal of Molecular Biology, 1984
- Processing of Glycoproteins Induced by Herpes Simplex Virus Type 1: Sulphation and Nature of the Oligosaccharide LinkagesJournal of General Virology, 1983