Fe‐dependent formation of a protein that makes mitochondria lipoxygenase‐susceptible during maturation of reticulocytes

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Abstract
During in vitro incubation the mitochondria of immature reticulocytes fail to be degraded by lipoxygenase and subsequent ATP‐dependent proteolysis. Susceptibility is conferred on the mitochondria by a protein, the ‘mitochondria susceptibility factor’ which is synthesized during maturation of the reticulocytes in an iron‐containing medium.