Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex
- 1 September 1997
- Vol. 27 (1) , 79-82
- https://doi.org/10.1002/(sici)1098-2396(199709)27:1<79::aid-syn8>3.0.co;2-a
Abstract
The distribution of 5-HT2A receptors in rat cortex was evaluated using newly developed antibodies. Each of three antibodies tested identified an identical pattern of 5-HT2A-like immunoreactivity (5-HT2A-li) in rat cortex with 5-HT2A-li showing a widespread distribution. The majority of 5-HT2A-li cells displayed a pyramidal morphology. While a minority, some cortical neurons with a bipolar morphology displayed 5-HT2A-li as well. Dual-label fluorescence confocal microscopic studies with a 5-HT2A antibody and a mouse monoclonal antibody to parvalbumin, a marker of a subset of gamma aminobutyric acid (GABA)ergic interneurons in the cortex, demonstrated that although some cells expressing 5-HT2A-li were interneurons, most were not. Synapse 27:79–82, 1997.Keywords
This publication has 16 references indexed in Scilit:
- Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugsJournal of Neuroscience, 1995
- Neurons Expressing 5-HT2 Receptors in the Rat Brain: Neurochemical Identification of Cell Types by ImmunocytochemistryNeuropsychopharmacology, 1994
- Electrophysiological evidence for a functional interaction between 5‐HT1A and 5‐HT2A receptors in the rat medial prefrontal cortex: An lontophoretic studySynapse, 1994
- Multiple Serotonin Receptors: Clinical and Experimental AspectsAnnals of Clinical Psychiatry, 1994
- Production and characterization of a specific 5-HT2 receptor antibodyBrain Research, 1993
- Immunocytochemical localization and description of neurons expressing serotonin2 receptors in the rat brainNeuroscience, 1993
- Parvalbumin immunoreactivity reveals layer IV of monkey cerebral cortex as a mosaic of microzones of thalamic afferent terminationsBrain Research, 1991
- 5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortexNeuroscience, 1991
- Localization of the mRNA for the 5-HT2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sitesBrain Research, 1990
- Correspondence between 5-HT2 receptors and serotonergic axons in rat neocortexBrain Research, 1988