On the Biochemical Nature of Triose- and Hexose- Stimulated Insulin Secretion*

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Abstract
The differential effects of several specific inhibitors of intermediary metabolism, mannoheptulose, 2-deoxylucose and iodoacetate, were studied with isolated perifused [rat] pancreatic islets stimulated with glucose, mannose, glyceraldehyde, dihydroxyacetone, or .alpha.-ketoisocaproate. Insulin release rates and/or capacities to metabolize these caloric stimuli served as indicators of the inhibitors'' actions. Mannoheptulose and 2-deoxyglucose blocked hexose-stimulated hormone release and hexose metabolism concomitantly, but left the functional and metabolic actions of trioses unaltered. Iodoacetate blocked hexose- and triose-stimulated hormone release as well as their metabolism in a parallel fashion. The action of .alpha.-ketoisocaproate was not affected by any of these 3 inhibitory agents. The data are most easily explained by a theory that incorporates metabolic signals, arising during the degradation of insulin-releasing fuel molecules, as an integral component in the process of .beta.-cell stimulation.

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