Effects of endotoxin and compound 48/80 on splenectomized dogs

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Abstract
Changes in plasma protein concentration, hematocrit, red cell-Cr51 concentration (counts/min per ml blood), albumin-I131 concentration (counts/min per ml plasma) arterial blood pH, PO2, PCO2, 02 hemoglobin saturation, and bicarbonate concentration were determined following single injections of [Escheri-chia coll] endotoxin and Compound 48/80 in splenectomized dogs on controlled positive-pressure breathing. There were marked increases in hematocrit, red cell-Cr51 concentration and red cell volume following injection of each substance. Plasma protein concentration decreased markedly and albumin-I131 concentration declined more than could be accounted for on the basis of a transfer of fluid into the circulation. These data indicate a shift of red cells out of reservoirs other than the spleen, a marked hemoconcentration due to loss of plasma and a possible increase in size of the red cells themselves. There were also decreases in arterial blood pH, PCO2, PO, O2 saturation, and bicarbonate concentration, indicating metabolic acidosis and underventilation of some of the alveoli.

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