Selective uptake of alloxan by pancreatic B-cells
- 15 November 1982
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 208 (2) , 513-515
- https://doi.org/10.1042/bj2080513
Abstract
Alloxan rapidly binds to or accumulates in pancreatic B-cells as distinct from non-B-cells. The selective uptake of this cytotoxic agent by the insulin-producing B-cells might account for its well-known diabetogenic effect.Keywords
This publication has 12 references indexed in Scilit:
- Islet cell analysis and purification by light scatter and autofluorescenceBiochemical and Biophysical Research Communications, 1982
- NONCARBOHYDRATE NUTRIENTS PROTECT AGAINST ALLOXAN-INDUCED INHIBITION OF INSULIN RELEASEEndocrinology, 1982
- Determinants of the selective toxicity of alloxan to the pancreatic B cell.Proceedings of the National Academy of Sciences, 1982
- Superoxide dismutase is a prophylactic against alloxan diabetesNature, 1981
- A method for the purification of single A, B and D cells and for the isolation of coupled cells from isolated rat isletsDiabetologia, 1981
- Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitroBiochemical Journal, 1979
- Alloxan Uptake by Isolated Rat Islets of Langerhans*Endocrinology, 1978
- Effect of Alloxan on Permeability and Hexose Transport in Rat Pancreatic IsletsEndocrinology, 1975
- Evidence for mediated transport of glucose in mammalian pancreatic β-cellsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1971
- Method for the Isolation of Intact Islets of Langerhans from the Rat PancreasDiabetes, 1967