Tetrodotoxin Does Not Block Excitation from Inside the Nerve Membrane
- 12 August 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 153 (3737) , 765-767
- https://doi.org/10.1126/science.153.3737.765
Abstract
Tetrodotoxin does not block the action potential or membrane sodium current when internally perfused through the giant axon of a squid at much higher concentrations than those required for blocking by external application. It is suggested that the gate for the sodium channel is located on the exterior surface of the axon, because tetrodotoxin is not lipid soluble.This publication has 26 references indexed in Scilit:
- Blockage of Sodium Conductance Increase in Lobster Giant Axon by Tarichatoxin (Tetrodotoxin)The Journal of general physiology, 1966
- Voltage Clamp Studies on Internally Perfused AxonsThe Journal of general physiology, 1965
- Potential, Structure, and Excitability of Giant Axon MembraneThe Journal of general physiology, 1965
- Restoration of action potential by anodal polarization in lobster giant axonsJournal of Cellular and Comparative Physiology, 1964
- Tarichatoxin—Tetrodotoxin: A Potent NeurotoxinScience, 1964
- Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant AxonsThe Journal of general physiology, 1964
- Delayed Rectification and Anomalous Rectification in Frog's Skeletal Muscle MembraneThe Journal of general physiology, 1962
- Replacement of the Protoplasm of a Giant Nerve Fibre with Artificial SolutionsNature, 1961
- Methods for Perfusing the Giant Axon of Loligo PealiiActa Physiologica Scandinavica, 1961
- ANESTHETIC AND CALCIUM ACTION IN THE VOLTAGE CLAMPED SQUID GIANT AXONThe Journal of general physiology, 1959