β-Adrenergic Receptors of Human Lymphocytes Are Unaltered by Hyperthyroidism*
- 1 March 1979
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 48 (3) , 503-505
- https://doi.org/10.1210/jcem-48-3-503
Abstract
Lymphocytes from 12 patients with untreated hyperthyroidism were compared to lymphocytes from age- and sex-matched euthyroid control subjects to test the hypothesis that alterations in β-adrenergic response mechanisms occur in human hyperthyroidism. The binding of (-)[3H]dihydroalprenolol, a compound previously shown in these cells to label binding sites having the characteristics of β-adrenergic receptors,was assayed and no significant difference was found between the two groups. In addition, the accumulation of cAMP in response to isoproterenol was determined by RIA and, again, no difference was found. (J Clin Endocrinol Metab48: 503, 1979)Keywords
This publication has 4 references indexed in Scilit:
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- Receptors for Peptide HormonesAnnals of Internal Medicine, 1977
- Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.Journal of Clinical Investigation, 1976
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