Vascular Responsiveness in Isolated Rat Lungs is Inversely Related to Blood Flow

Publisher Website
Google Scholar
Abstract
The pulmonary pressor responses to prostaglandin F2.alpha., 5-hydroxytryptamine, angiotensin II and alveolar hypoxia were significantly increased when blood flow was reduced from 10 to 5 ml/min in isolated perfused rat lungs. When blood flow was increased from 10 to to 15 ml/min, the pressor responses to hypoxia and angiotensin II were reduced. The changes in pulmonary vascular reactivity with alterations in blood flow apparently were due to vessel distension and changes in vessel wall-to-lumen ratios and consequent effects on mechanical contractile efficiency.

This publication has 0 references indexed in Scilit: