Induction of De Novo Subcortical Actin Filament Assembly by Treponema denticola Major Outer Sheath Protein
Open Access
- 1 June 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (6) , 3650-3654
- https://doi.org/10.1128/iai.72.6.3650-3654.2004
Abstract
Treponema denticola and its major outer sheath protein (Msp) induce actin reorganization in fibroblasts. We adapted a barbed-end labeling/imaging assay to monitor Msp-induced subcortical actin filament assembly in neutrophils and fibroblasts. Msp, at an actin-reorganizing concentration, inhibited migration of these dissimilar cell types, whose cytoskeletal functions in locomotion and phagocytosis are crucial for immunity and healing of peripheral infections.Keywords
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