Functional Analysis of the p53 Pathway in Response to Ionizing Radiation in Uveal Melanoma

Open Access

1 May 2005

journal article
Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science

Vol. 46 (5) , 1561-1564
https://doi.org/10.1167/iovs.04-1362

Abstract

Purpose. Uveal melanomas are notoriously radioresistant and thus necessitate treatment with extremely high radiation doses that often cause ocular complications. The p53 tumor suppressor pathway is a major mediator of the cellular response to radiation-induced DNA damage, suggesting that this pathway may be defective in uveal melanoma. The current study was conducted to analyze the functional integrity of the p53 pathway in primary uveal melanoma cells.

Keywords

DIPLOID
P53 PATHWAY
DNA DAMAGE
UVEAL MELANOMA
RESPONSE TO RADIATION
CELL LINES
GENE WAS SEQUENCED

This publication has 0 references indexed in Scilit: