RENAL EXCRETION KINETICS OF HIGH-DOSE CIS-DICHLORODIAMMINEPLATINUM(II) ADMINISTERED WITH HYDRATION AND MANNITOL DIURESIS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 63  (1) , 13-16
Abstract
The effect of hydration and mannitol diuresis on the nephrotoxicity and renal excretion kinetics of high-dose cis-dichlorodiammineplatinum(II) [cis-Pt] was examined in 7 men undergoing treatment for testicular or bladder carcinoma. The elimination half-life averaged 26.8 h, shorter than values previously reported from studies not employing hydration and diuresis. No signs of nephrotoxicity were observed. Hydration and mannitol diuresis apparently decrease the nephrotoxicity of cis-Pt by increasing its rate of elimination.