Dopaminergic and Ligand-Independent Activation of Steroid Hormone Receptors
- 13 December 1991
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 254 (5038) , 1636-1639
- https://doi.org/10.1126/science.1749936
Abstract
The current view of how steroid hormone receptors affect gene transcription is that these receptors, on binding ligand, change to a state in which they can interact with chromatin and regulate transcription of target genes. Receptor activation is believed to be dependent only on this ligand-binding event. Selected steroid hormone receptors can be activated in a ligand-independent manner by a membrane receptor agonist, the neurotransmitter dopamine. In vitro, dopamine faithfully mimicked the effect of progesterone by causing a translocation of chicken progesterone receptor (cPR) from cytoplasm to nucleus. Dual activation by progesterone and dopamine was dissociable, and a serine residue in the cPR was identified that is not necessary for progesterone-dependent activation of cPR, but is essential for dopamine activation of this receptor.Keywords
This publication has 48 references indexed in Scilit:
- CREB: a Ca 2+ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent KinasesScience, 1991
- Phosphorylation of the v-erbA protein is required for its function as an oncogene.Genes & Development, 1990
- Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neurolepticsNature, 1990
- Molecular cloning and expression of the gene for a human D1 dopamine receptorNature, 1990
- Mechanisms of nuclear localization of the progesterone receptor: Evidence for interaction between monomersCell, 1989
- The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNABiochemical and Biophysical Research Communications, 1987
- A possible role for dephosphorylation in glucocorticoid receptor transformationThe Journal of Steroid Biochemistry and Molecular Biology, 1987
- STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKSAnnual Review of Genetics, 1985
- A Sex Difference in the Progestin Receptor System of Guinea Pig BrainNeuroendocrinology, 1980
- A two-step mechanism for the interaction of estradiol with rat uterus.Proceedings of the National Academy of Sciences, 1968