Reverse Phase Ion Pair High Performance Liquid Chromatography of Viral Tryptic Glycopeptides

Abstract
Tryptic glycopeptides from influenza A/WSN (H0N1) and mink cell focus(MCF)-inducing (MCF-247) murine leukemia virus were subjected to high performance liquid chromatography (HPLC) for mapping purposes. Hydrophilic ion-pairing was accomplished using 0.1% phosphoric acid on C18 .mu.Bondapack and LiChrosorb RP-18 ODS commercially available columns. The samples were eluted from the column with acetonitrile with sample recovery in the range of 70-80%. The advantages of HPLC over the conventional techniques previously used are detailed.