Effect of Inorganic Lead on Rat Brain Mitochondrial Respiration and Energy Production
- 1 March 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 36 (3) , 1109-1113
- https://doi.org/10.1111/j.1471-4159.1981.tb01706.x
Abstract
Toxicologically significant amounts of inorganic lead were added to rat brain mitochondrial preparations that did not contain EDTA or Pi. The binding of the lead to the mitochondria was measured by anodic stripping voltometry. In the presence of lead, the respiratory control ratios decreased, implying a decrease in the degree of dependence of respiration on a phosphate acceptor. Nucleotide contents were also measured, and in the presence of inorganic lead the actual amounts of ATP formed from ADP were found to be significantly decreased as well.Keywords
This publication has 13 references indexed in Scilit:
- In vitro effects of inorganic lead on isolated rat brain mitochondrial respirationNeurochemical Research, 1978
- Lead encephalopathy: the significance of lead inhibition of calcium uptake by brain mitochondriaBrain Research, 1977
- A COMPARATIVE STUDY OF DIHYDROXYLATED PHENOTHIAZINE DERIVATIVES AS MITOCHONDRIAL INHIBITORSJournal of Neurochemistry, 1977
- The effect of lead on the calcium-handling capacity of rat heart mitochondriaBiochemical Journal, 1976
- Early Effects of Inorganic Lead on Immature Rat Brain Mitochondrial RespirationPediatric Research, 1976
- A lead-induced behavioral disorderLife Sciences, 1973
- Ion transport by heart mitochondriaArchives of Biochemistry and Biophysics, 1971
- Lead encephalo-myelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseasesActa Neuropathologica, 1966
- The Respiratory Chain and Oxidative PhosphorylationPublished by Wiley ,1956