Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease
- 1 November 1988
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Neurologie
- Vol. 235 (8) , 466-471
- https://doi.org/10.1007/bf00314249
Abstract
A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.Keywords
This publication has 24 references indexed in Scilit:
- Antivascular Antibodies in the Sera of Patients With Senile Dementia of the Alzheimer's TypeJournal of Gerontology, 1987
- A cell-surface antigen of cholinergic nerve terminals recognized by antisera to choline acetyltransferaseNeuroscience Letters, 1986
- Specific lysis of noradrenergic synaptosomes by an antiserum to dopamine‐β‐hydroxylaseFEBS Letters, 1986
- Antibodies To Cholinergic Cell Bodies In Alzheimer’s DiseasePublished by Springer Nature ,1986
- Clinical subtypes of dementia of the Alzheimer typeNeurology, 1985
- Evidence for specific immunolysis of nerve terminals using antisera against choline acetyltransferase, glutamate decarboxylase and tyrosine hydroxylaseBrain Research, 1985
- Albumin and immunoglobulin in plasma and cerebrospinal fluid, and blood-cerebrospinal fluid barrier function in patients with dementia of alzheimer type and multi-infarct dementiaJournal of the Neurological Sciences, 1983
- Lysis of cholinergic synaptosomes by an antiserum to choline acetyltransferaseBiochemical Society Transactions, 1982
- Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer TypeThe British Journal of Psychiatry, 1979
- DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMESJournal of Neurochemistry, 1973