Effect of Tetraethylammonium Chloride on Mammalian Skeletal Muscle Action
- 31 January 1952
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 168 (2) , 442-445
- https://doi.org/10.1152/ajplegacy.1952.168.2.442
Abstract
Tetraethylammonium chloride (TEAC) injd. into the femoral artery of anesthetized dogs diminished the contraction of the gastrocnemius muscle stimulated through its motor nerve. The diminution was greater the larger the dose. Contraction in response to direct stimulation of the muscle was increased with small doses of TEAC and decreased with large doses. No effect was produced by soaking the nerve in TEAC. Injn. of TEAC into the brachial artery of unanesthetized humans produced varying degrees of paralysis of the muscles of the forearm on the injd. side. All observed effects of TEAC were completely reversible.Keywords
This publication has 2 references indexed in Scilit:
- THE ACTION OF TETRAETHYLAMMONIUM ION ON THE MAMMALIAN CIRCULATION1946
- Further studies on the pharmacological properties of onium saltsProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1933