CHANGES IN HUMAN MUSCLES AFTER PERMANENT TENOTOMY

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Abstract
Studies were made on samples of tenotomized human muscles from amputation stumps and of muscles with undisturbed attachments but subjected to limited activity due to the amputation. The atrophy in the tenotomized muscles was 39-69% while that in the muscles with limited activity was 16-28%. Histologically an apparent increase in connective tissue was noted but actually an overall reduction in connective tissue and muscle tissue has occurred so the connective tissue increase was relative and not absolute. There were no significant changes in the motor end plates, neuro-muscular spindles or nuclei of the atrophied fibers and no abnormalities in blood vessels or the vascular pattern.