Preparation of (1R )[1—2H]- and (1S)[1—2H]-Alcohols by Exchange Reactions Catalyzed by Yeast or a Coupled Enzyme System
Open Access
- 1 June 1973
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 28 (5-6) , 241-246
- https://doi.org/10.1515/znc-1973-5-603
Abstract
All possible enantiomers of stereospecifically labelled [1-2H] ethanol, propanol and butanol have been prepared on a scale of up to 7 ml. The R forms have been obtained by incubation of the alcohols with alcohol dehydrogenase and diaphorase (NAD: Lipoamide oxidoreductase, EC 1.6.4.3) in presence of catalytic amounts of NAD+/NADH in deuterium oxide. The S forms have been prepared with the same enzymes in ordinary water, from the corresponding [1,1-2H] alcohols. (IS) [1-2H] ethanol was prepared from [1,1-2H] ethanol and ordinary water, by a yeast catalyzed exchange reaction.Keywords
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