FURTHER STUDIES ON THE ALLEGED INTERRELATIONSHIP OF THE PANCREAS AND THE THYROID

1 December 1927

journal article
research article
Published by American Physiological Society in American Journal of Physiology-Legacy Content

Vol. 83 (1) , 134-140
https://doi.org/10.1152/ajplegacy.1927.83.1.134

Abstract

Thyroid extract was fed to partially (I) pancreatectomized dogs. To control the hyper-thermic effect of thyroid feeding hyperpyrexia was induced by injecting 10% Na nucleinate. To control, possibly, the effect of heightened basal metabolism due to thyroid feeding, quinine was fed to a number of dogs. The animate were kept on a constant standard diet. Blood and urinary sugar determinations were made daily. Thyroid extract in an animal with an intact pancreas produced no effect on blood sugar. In the borderline cases (i partially pancreatectomized) hyperglycemia and a glycosuria associated with fever resulted. Na nucleinate produced fever and caused hyperglycemia even in the normal animal. Quinine, a drug generally assumed to diminish basal metabolism, gave no influence on the hyperglycemic trend. It is concluded that there is an indirect relationship between thyroid and pancreas.

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