PHENTOLAMINE BLOCKS THE SOMATOSTATIN-MEDIATED INHIBITION OF INSULIN SECRETION
- 1 April 1976
- journal article
- Published by The Endocrine Society in Endocrinology
- Vol. 98 (4) , 1073-1076
- https://doi.org/10.1210/endo-98-4-1073
Abstract
This study was undertaken to determine the influence of alpha-adrenergic blockade upon the somatostatin-mediated inhibition of insulin secretion. Somatostatin inhibited both the basal and glucose-stimulated pancreaticoduodenal vein insulin output of dogs. This effect was not observed during a simultaneous infusion of phentolamine, an alpha-adrenergic blocker. It is proposed that alpha-adrenergic mechanisms play a role in the inhibition of insulin secretion by somatostatin.Keywords
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